N=4 Supergravity with Antisymmetric Tensor in Central Charge Superspace

A concise geometrical formulation of N=4 supergravity containing an antisymmetric tensor gauge field is given in central charge superspace: graviphotons are identified in the super-vielbein on the same footing as the vierbein and the Rarita-Schwinger fields. As a consequence of superspace soldering, Chern-Simons terms in the fieldstrength of the antisymmetric tensor arise as an intrinsic property of superspace with central charge coordinates.Comment: Latex, 13 pages, minor clarification about a referenc

Kraftforsyningsmodul for ROV

Konkurransen som UiS Subsea skal delta i, er arrangert av Marine Advanced Technology Education Center (MATE), og skal avholdes på Long Beach utenfor Los Angeles, California, USA. Årets Remotely Operated Vehicle (ROV) har fått nye oppgaver som den skal utføre ved hjelp av en pilot, og om mulig, autonomt. I tillegg skal ROV-en delta i en konkurranse kalt TAC challenge, som holdes på Tau i Rogaland. Rapporten tar for seg utviklingen av en kraftforsyningsmodul som skal utvikles for å regulere ned spenning og distribuere ulike spenningsnivåer på en ROV. I tillegg skal de utvendige lysene styres fra modulen. Fra land er ROV-en forbundet med en forsterket bunt kraftledere og kommunikasjonkabler som kalles en Navlestreng. Problemstillingen er ikke ny, så det har blitt tatt inspirasjon fra tidligere prosjekter, hvor noen konsepter har blitt videreført, mens andre konsepter er helt nye. Det har blitt gjort analyser, simuleringer og dimensjoneringer for å opprettholde tilfredsstillende krav til spenningsfall, filtrering av høyfrekvent støy og rippelspenning for beregne ulike typer kondensa- torbanker. Den samlede kraftforsyningsmodulen ble designet på et Printed Circuit Board (PCB), som skulle kunne passe inn i en sylinder, med andre kretskort. Dette krevde god koordinering med de andre gruppene, for å få dette til å passe sammen. Det ble også egenutviklet sikringskretser da fjor- årets Integrated Circuit (IC)-er ikke lenger var i produksjon, og det ble ikke funnet tilfredsstillende ekvivalente IC-er. Det er også være mulighet for å skru av strømmen til ROV-ens motorer. For kraftoverføring og kommunikasjon ble det tatt i bruk et felles grensesnitt via en multibuss, som supplerer jevne spenninger på et tilfredsstillende nivå for ikke å risikere uventede brå spenningsfall1. Informasjonsflyten går over et Controller Area Network (CAN)-grensesnitt, som er forbundet med de andre gruppenes Micro Control Unit (MCU)-er via den samme multibussen. Under produksjon ble det støtt på noen utfordringer. Et fotavtrykk til en komponent var feil under produksjon, CAN-bussen var konfigurert feil, sikringene ble initielt stilt inn til for lave verdier og noen jordingspunkt ble ikke jordet da jordingsplanet ikke koble seg til dem i Altium Designer. Kraftforsyningen som ble produsert har bestått kravene som ble satt for det, det ble levert stabile spenninger til effektforbrukerne, og det ble funnet gode løsninger til utfordringer som oppsto.The competition, which UiS Subsea will participate in, is organized by the Marine Advanced Technology Education Center (MATE), and will be held on Long Beach outside Los Angeles, California, USA. This year's Remotely Operated Vehicle (ROV) has been given new tasks to perform using a pilot, and if possible, autonomously. In addition, the ROV will participate in a competition called TAC challenge, which is held at Tau in Rogaland. The ROV is supplied from land used a dual power and fibre cable commonly called an umbilical. The issue is not new, so inspiration has been taken from previous projects, where some concepts have been continued, while other concepts are completely new. Analysis, simulations and dimensioning have been performed to maintain satisfactory requirements for voltage drops, high frequency filtering and ripple voltage filtering to calculate different types of capacitor banks. The overall power supply module was designed on a Printed Circuit Board (PCB), which could fit into a cylinder, with other circuit boards. This required good coordination with the other groups, to fit all together. Inhouse safety circuits were also developed, as last year's Integrated Circuit (IC) were no longer in production, and no satisfactorily equivalent ICs were found. It is also possible to turn off the power supply to the ROV's motors. For power transmission and communication, a common interface was used via a multibus, supplementing even voltages at a satisfactory level so as not to risk unexpected sudden voltage drops.The information is conveyed over a Controller Area Network (CAN) interface, which is connected to other groups Micro Control Units (MCU) via the same multibus. During production, some challenges were encountered. A footprint of a component was incorrect under production, the CAN bus was configured incorrectly, the fuses were initially set at to too low values ​​and some grounding points were not connected to ground to the grounding plane did not connect to them in Altium Designer. The power supply that was produced has passed the requirements that were set for it, stable voltages were delivered to the power consumers, and good solutions were found for the challenges that arose

Kraftforsyningsmodul for ROV

Konkurransen som UiS Subsea skal delta i, er arrangert av Marine Advanced Technology Education Center (MATE), og skal avholdes på Long Beach utenfor Los Angeles, California, USA. Årets Remotely Operated Vehicle (ROV) har fått nye oppgaver som den skal utføre ved hjelp av en pilot, og om mulig, autonomt. I tillegg skal ROV-en delta i en konkurranse kalt TAC challenge, som holdes på Tau i Rogaland. Rapporten tar for seg utviklingen av en kraftforsyningsmodul som skal utvikles for å regulere ned spenning og distribuere ulike spenningsnivåer på en ROV. I tillegg skal de utvendige lysene styres fra modulen. Fra land er ROV-en forbundet med en forsterket bunt kraftledere og kommunikasjonkabler som kalles en Navlestreng. Problemstillingen er ikke ny, så det har blitt tatt inspirasjon fra tidligere prosjekter, hvor noen konsepter har blitt videreført, mens andre konsepter er helt nye. Det har blitt gjort analyser, simuleringer og dimensjoneringer for å opprettholde tilfredsstillende krav til spenningsfall, filtrering av høyfrekvent støy og rippelspenning for beregne ulike typer kondensatorbanker. Den samlede kraftforsyningsmodulen ble designet på et Printed Circuit Board (PCB), som skulle kunne passe inn i en sylinder med andre kretskort. Dette krevde god koordinering med deandre gruppene, for å få dette til å passe sammen. Det ble også egenutviklet sikringskretser da fjorårets Integrated Circuit (IC)-er ikke lenger var i produksjon, og det ble ikke funnet tilfredsstillende ekvivalente IC-er. Det er også være mulighet for å skru av strømmen til ROV-ens motorer. For kraftoverføring og kommunikasjon ble det tatt i bruk et felles grensesnitt via en multibuss, som supplerer jevne spenninger på et tilfredsstillende nivå for ikke å risikere uventede brå spenningsfall. Informasjonsflyten går over et Controller Area Network (CAN)-grensesnitt, som er forbundet med de andre gruppenes Micro Control Unit (MCU)-er via den samme multibussen. Under produksjon ble det støtt på noen utfordringer. Et fotavtrykk til en komponent var feil underproduksjon, CAN-bussen var konfigurert feil, sikringene ble initielt stilt inn til for lave verdier ognoen jordingspunkt ble ikke jordet da jordingsplanet ikke koble seg til dem iAltium Designer. Kraftforsyningen som ble produsert har bestått kravene som ble satt for det, det ble levert stabilespenninger til effektforbrukerne, og det ble funnet gode løsninger til utfordringer som oppsto.The competition, which UiS Subsea will participate in, is organized by the Marine Advanced Technology Education Center (MATE), and will be held on Long Beach outside Los Angeles, California, USA. This year's Remotely Operated Vehicle (ROV) has been given new tasks to perform using a pilot, and if possible, autonomously. In addition, the ROV will participate in a competition called TAC challenge, which is held at Tau in Rogaland. The ROV is supplied from land used a dual power and fibre cable commonly called an umbilical. The issue is not new, so inspiration has been taken from previous projects, where some concepts have been continued, while other concepts are completely new. Analysis, simulations and dimensioning have been performed to maintain satisfactory requirements for voltage drops, high frequency filtering and ripple voltage filtering to calculate different types of capacitor banks. The overall power supply module was designed on a Printed Circuit Board (PCB), which could fit into a cylinder, with other circuit boards. This required good coordination with the other groups, to fit all together. Inhouse safety circuits were also developed, as last year's Integrated Circuit (IC) were no longer in production, and no satisfactorily equivalent ICs were found. It is also possible to turn off the power supply to the ROV's motors. For power transmission and communication, a common interface was used via a multibus, supplementing even voltages at a satisfactory level so as not to risk unexpected sudden voltage drops.The information is conveyed over a Controller Area Network (CAN) interface, which is connected to other groups Micro Control Units (MCU) via the same multibus. During production, some challenges were encountered. A footprint of a component was incorrect under production, the CAN bus was configured incorrectly, the fuses were initially set at to too low values ​​and some grounding points were not connected to ground to the grounding plane did not connect to them in Altium Designer. The power supply that was produced has passed the requirements that were set for it, stable voltages were delivered to the power consumers, and good solutions were found for the challenges that arose

Kraftforsyningsmodul for ROV

Konkurransen som UiS Subsea skal delta i, er arrangert av Marine Advanced Technology Education Center (MATE), og skal avholdes på Long Beach utenfor Los Angeles, California, USA. Årets Remotely Operated Vehicle (ROV) har fått nye oppgaver som den skal utføre ved hjelp av en pilot, og om mulig, autonomt. I tillegg skal ROV-en delta i en konkurranse kalt TAC challenge, som holdes på Tau i Rogaland. Rapporten tar for seg utviklingen av en kraftforsyningsmodul som skal utvikles for å regulere ned spenning og distribuere ulike spenningsnivåer på en ROV. I tillegg skal de utvendige lysene styres fra modulen. Fra land er ROV-en forbundet med en forsterket bunt kraftledere og kommunikasjonkabler som kalles en Navlestreng. Problemstillingen er ikke ny, så det har blitt tatt inspirasjon fra tidligere prosjekter, hvor noen konsepter har blitt videreført, mens andre konsepter er helt nye. Det har blitt gjort analyser, simuleringer og dimensjoneringer for å opprettholde tilfredsstillende krav til spenningsfall, filtrering av høyfrekvent støy og rippelspenning for beregne ulike typer kondensatorbanker. Den samlede kraftforsyningsmodulen ble designet på et Printed Circuit Board (PCB), som skulle kunne passe inn i en sylinder, med andre kretskort. Dette krevde god koordinering med de andre gruppene, for å få dette til å passe sammen. Det ble også egenutviklet sikringskretser da fjorårets Integrated Circuit (IC)-er ikke lenger var i produksjon, og det ble ikke funnet tilfredsstillende ekvivalente IC-er. Det er også være mulighet for å skru av strømmen til ROV-ens motorer. For kraftoverføring og kommunikasjon ble det tatt i bruk et felles grensesnitt via en multibuss, som supplerer jevne spenninger på et tilfredsstillende nivå for ikke å risikere uventede brå spenningsfall1. Informasjonsflyten går over et Controller Area Network (CAN)-grensesnitt, som er forbundet med de andre gruppenes Micro Control Unit (MCU)-er via den samme multibussen. Under produksjon ble det støtt på noen utfordringer. Et fotavtrykk til en komponent var feil under produksjon, CAN-bussen var konfigurert feil, sikringene ble initielt stilt inn til for lave verdier og noen jordingspunkt ble ikke jordet da jordingsplanet ikke koble seg til dem i Altium Designer. Kraftforsyningen som ble produsert har bestått kravene som ble satt for det, det ble levert stabile spenninger til effektforbrukerne, og det ble funnet gode løsninger til utfordringer som oppsto.The competition, which UiS Subsea will participate in, is organized by the Marine Advanced Technology Education Center (MATE), and will be held on Long Beach outside Los Angeles, California, USA. This year's Remotely Operated Vehicle (ROV) has been given new tasks to perform using a pilot, and if possible, autonomously. In addition, the ROV will participate in a competition called TAC challenge, which is held at Tau in Rogaland. The ROV is supplied from land used a dual power and fibre cable commonly called an umbilical. The issue is not new, so inspiration has been taken from previous projects, where some concepts have been continued, while other concepts are completely new. Analysis, simulations and dimensioning have been performed to maintain satisfactory requirements for voltage drops, high frequency filtering and ripple voltage filtering to calculate different types of capacitor banks. The overall power supply module was designed on a Printed Circuit Board (PCB), which could fit into a cylinder, with other circuit boards. This required good coordination with the other groups, to fit all together. Inhouse safety circuits were also developed, as last year's Integrated Circuit (IC) were no longer in production, and no satisfactorily equivalent ICs were found. It is also possible to turn off the power supply to the ROV's motors. For power transmission and communication, a common interface was used via a multibus, supplementing even voltages at a satisfactory level so as not to risk unexpected sudden voltage drops.The information is conveyed over a Controller Area Network (CAN) interface, which is connected to other groups Micro Control Units (MCU) via the same multibus. During production, some challenges were encountered. A footprint of a component was incorrect under production, the CAN bus was configured incorrectly, the fuses were initially set at to too low values ​​and some grounding points were not connected to ground to the grounding plane did not connect to them in Altium Designer. The power supply that was produced has passed the requirements that were set for it, stable voltages were delivered to the power consumers, and good solutions were found for the challenges that arose

Budget impact of sequential treatment with first-line afatinib versus first-line osimertinib in non-small-cell lung cancer patients with common EGFR mutations

Background The therapeutic landscape for non-small-cell lung cancer (NSCLC) patients that have common epidermal growth factor receptor (EGFR) mutations has changed radically in the last decade. The availability of these treatment options has an economic impact, therefore a budget impact analysis was performed. Methods A budget impact analysis was conducted from a Dutch healthcare perspective over a 5-year time horizon in EGFR-mutant NSCLC patients receiving first-line afatinib (Gilotrif(R)) versus first-line osimertinib (Tagrisso(R)), followed by subsequent treatments. A decision analysis model was constructed in Excel. Scenario analyses and one-way sensitivity analysis were used to test the models' robustness. Results Sequential treatment with afatinib versus first-line treatment with osimertinib showed mean total time on treatment (ToT) of 29.1 months versus 24.7 months, quality-adjusted life months (QALMs) of 20.2 versus 17.4 with mean cost of euro108,166 per patient versus euro143,251 per patient, respectively. The 5-year total budget impact was euro110.4 million for the afatinib sequence versus euro158.6 million for the osimertinib sequence, leading to total incremental cost savings of euro48.15 million. Conclusions First-line afatinib treatment in patients with EGFR-mutant NSCLC had a lower financial impact on the Dutch healthcare budget with a higher mean ToT and QALM compared to osimertinib sequential treatment

Nalaquq (“it is found”) : a knowledge co-production framework for environmental sensing and communication in Indigenous arctic communities

Funding Funding provided by Hampden-Sydney College, Nalaquq, LLC, Qanirtuuq Incorporated, and Quinhagak Heritage Incorporated.Peer reviewedPublisher PD

The Nuclear Spectroscopic Telescope Array (NuSTAR)

The Nuclear Spectroscopic Telescope Array (NuSTAR) is a NASA Small Explorer mission that will carry the first focusing hard X-ray (5 -- 80 keV) telescope to orbit. NuSTAR will offer a factor 50 -- 100 sensitivity improvement compared to previous collimated or coded mask imagers that have operated in this energy band. In addition, NuSTAR provides sub-arcminute imaging with good spectral resolution over a 12-arcminute field of view. After launch, NuSTAR will carry out a two-year primary science mission that focuses on four key programs: studying the evolution of massive black holes through surveys carried out in fields with excellent multiwavelength coverage, understanding the population of compact objects and the nature of the massive black hole in the center of the Milky Way, constraining explosion dynamics and nucleosynthesis in supernovae, and probing the nature of particle acceleration in relativistic jets in active galactic nuclei. A number of additional observations will be included in the primary mission, and a guest observer program will be proposed for an extended mission to expand the range of scientific targets. The payload consists of two co-aligned depth-graded multilayer coated grazing incidence optics focused onto solid state CdZnTe pixel detectors. To be launched in early 2012 on a Pegasus rocket into a low-inclination Earth orbit. Data will be publicly available at GSFC's High Energy Astrophysics Science Archive Research Center (HEASARC) following validation at the science operations center located at Caltech.Comment: 9 pages, 5 figures, to appear in Proceedings of the SPIE, Space Telescopes and Instrumentation 2010: Ultraviolet to Gamma Ra

Liver transplantation in patients with post-hepatectomy liver failure - A Northern European multicenter cohort study

Background: Liver transplantation (LTX) has been described as a rescue treatment option in severe, intractable post-hepatectomy liver failure (PHLF), but is not considered to be indicated for this condition by many hepatobiliary and transplant surgeons. In this article we describe the clinical experience of five northern European tertiary centers in using LTX to treat selected patients with severe PHLF. Methods: All patients subjected to LTX due to PHLF at the participating centers were identified from prospective clinical databases. Preoperative variables, surgical outcome (both resection surgery and LTX) and follow-up data were assessed.Results: A total of 10 patients treated with LTX due to severe PHLF from September 2008 to May 2020 were identified and included in the study. All patients but one were male and the median age was 70 years (range 49-72). In all patients the indication for liver resection was suspected malignancy, but in six patients post-resection pathology revealed benign or pre-malignant disease. There was no 90-day mortality after LTX. Patients were followed for a median of 49 months (13-153) and eight patients were alive without recurrence at last follow-up.Discussion: In selected patients with PHLF LTX can be a life-saving procedure with low short-term risk.Peer reviewe